Status:
COMPLETED
Leukapheresis to Obtain Lymphocytes for Studies on Antiretroviral Naive HIV-infected Patients
Lead Sponsor:
Canadian Immunodeficiency Research Collaborative
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Human Immunodeficiency Virus
Eligibility:
All Genders
18-50 years
Brief Summary
To further investigate differences in the immunologic function of various lymphocyte subsets in HIV-infected patients who are treated early in their infection and during the chronic phase of the infec...
Detailed Description
Primary HIV-1 infected and chronically infected individuals will be recruited and leukapheresis will be performed. This one year study requires that patients be apheresed once before initiating therap...
Eligibility Criteria
Inclusion
- Adult HIV-1 infected patient
- For primary infected patients anyone with an exposure to a known source of HIV infected material or individual, with symptoms and signs if present consistent with primary HIV infection, a negative ELISA, indeterminate Western blot for HIV and a positive HIV plasma RNA levels \> 10,000 copies/mL by either RT-PCR or bDNA
- Chronic HIV-infected patients should have a positive ELISA and a confirmatory western blot and willingness to give informed consent for the storage of blood.
- Willingness to be able to make follow-up visits for apheresis at 6 and 12 months for those who undergo antiretroviral therapy
Exclusion
- Pregnant women
Key Trial Info
Start Date :
August 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
220 Patients enrolled
Trial Details
Trial ID
NCT00333892
Start Date
August 1 2003
End Date
December 1 2008
Last Update
June 5 2012
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