Status:
TERMINATED
Does An Abnormal PFA 100 Predict Bleeding After Renal Biopsy?
Lead Sponsor:
University of Mississippi Medical Center
Conditions:
Kidney Failure, Acute
Kidney Failure, Chronic
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The kidneys are highly vascular organs and any trauma or surgery poses risk of severe bleeding. Platelet function is an integral part of the blood clotting during the initial, so-called vascular phase...
Detailed Description
Many patients with advanced chronic kidney disease have a predisposition to bleed. This predisposition becomes problematic when they have to undergo an invasive procedure such as a renal biopsy. There...
Eligibility Criteria
Inclusion
- Will offer enrollment to essentially all patients undergoing standard percutaneous renal biopsy here at the University Medical Center. These are:
- age 18-80, Body Mass Index (BMI) \<35, Modification of Diet in Renal Diseases (MDRD) calculated Glomerular Filtration Rate (GFR) \>10 cc/minute/1.73 m2, Hematocrit \>25, platelet count \>100,000/mm3, normal activated Prothrombin Time (aPT)/activated Partial Thromboplastin Time (aPTT).
Exclusion
- (essentially the contraindications to a standard percutaneous renal biopsy) known bleeding disorder, history of prior bleeding with procedure or known ongoing bleeding at the time of the procedure, Hematocrit \<25, Platelet count \<100, abnormal aPT/aPTT pre biopsy, small kidney(s) \< 8.0 cm multiple bilateral renal cyst or masses, hydronephrosis, active urinary tract infection, recent nonsteroidal anti-inflammatory drug use.
- \-
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT00334204
Start Date
August 1 2004
End Date
December 1 2008
Last Update
August 1 2013
Active Locations (1)
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1
University of Mississipppi Medical Center, Adult Hospital
Jackson, Mississippi, United States, 39216