Status:
COMPLETED
Gait Training and Brain Changes in Stroke Patients
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Gait Training
Locomotion
Eligibility:
All Genders
18-80 years
Brief Summary
This study, conducted in collaboration with the National Rehabilitation Hospital (NRH) in Washington, D.C., will look at changes in brain activation and brain responses that occur with gait (walking) ...
Detailed Description
OBJECTIVES: The purpose of this protocol is to study the mechanisms underlying the beneficial effects of locomotor training in hemiplegic patients. The locomotor training will be performed under an a...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Stroke Patients
- May be eligible for this research study if they:
- qualified for participation in the NRH locomotor protocol
- are between 18 and 80 years old
- have not had any other strokes
- had a stroke more than 3 months ago
- had a stroke that affected one side of the brain
- are able to perform the tasks required in the study with the paretic or non-paretic foot
- are willing and able to give consent
- Healthy Volunteers
- May be eligible for the research study if they:
- are between 18 and 80 years old
- are able to perform the tasks required in the study
- are willing and able to give consent
- a normal physical and neurological examination
- EXCLUSION CRITERIA:
- Exclusion criteria for stroke patients:
- Sub-acute stroke patients will be not be eligible for the study if they:
- are unable to perform the behavioral tasks with the non-paretic foot,
- have had more than one stroke,
- have a history of alcohol or drug abuse or severe language disturbances (aphasia)
- have uncontrolled medical problems, such as heart, lung or kidney disease, epilepsy or diabetes mellitus,
- are pregnant. Since the effects of MRI and TMS on fetal development are unknown, women of childbearing age will have pregnancy test prior to the study and pregnant women will be excluded.
- have a cardiac pacemaker, intracardiac lines, implanted medication pumps, neural stimulators, metal in the cranium, with the exception or dental braces in the mouth.
- simultaneous participation in any other intervention protocol for stroke.
- have with serious cognitive deficits (defined as equivalent to a mini-mental state exam score (MMSE) of 23 or less)
- Exclusion criteria for healthy volunteers:
- Healthy volunteers will not be eligible for the study if they:
- are unable to perform the tasks,
- have a history of alcohol or drug abuse or severe language disturbances or serious cognitive deficits,
- have uncontrolled medical problems, such as heart, lung or kidney disease, epilepsy or diabetes mellitus,
- are pregnant. Since the effects of MRI and TMS on fetal development are unknown, women of childbearing age will have pregnancy test prior to the study and pregnant women will be excluded.
- have a cardiac pacemaker, intracardiac lines, implanted medication pumps, neural stimulators, metal in the cranium except in the mouth, dental braces.
Exclusion
Key Trial Info
Start Date :
June 2 2006
Trial Type :
OBSERVATIONAL
End Date :
April 21 2008
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT00334230
Start Date
June 2 2006
End Date
April 21 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892