Status:
COMPLETED
TSH Receptor Antibody Heterogeneity in Children and Adolescents With Graves' Disease
Lead Sponsor:
Boston Children's Hospital
Conditions:
Graves' Disease
Eligibility:
All Genders
2-21 years
Brief Summary
Graves' disease, the most common form of hyperthyroidism in children, is caused by Thyrotropin (TSH) Receptor Antibodies (TRAbs) that mimic the action of TSH. The disease leads to significant morbidit...
Detailed Description
In the present grant proposal, we plan to utilize two new assays (binding and bioassay) in order to identify additional predictors of Graves' disease and apply them to a well characterized group of pa...
Eligibility Criteria
Inclusion
- Age 2-21 years
- Suppressed Thyroid Stimulating Hormone (TSH)
- Elevated Triiodothyronine (T3), Thyroxine (T4)
Exclusion
- Pregnancy
- Toxic Nodule
- Currently receiving steroids or thyroid hormone replacement
- Bacterial, Viral, Radiation, or Autoimmune thyroiditis
Key Trial Info
Start Date :
August 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00335062
Start Date
August 1 2005
End Date
February 1 2010
Last Update
July 25 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Childrens' Hospital Boston
Boston, Massachusetts, United States, 02115