Status:
COMPLETED
Efficacy of Lansoprazole in Chronic Post Nasal Drip
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
TAP Pharmaceutical Products Inc.
Conditions:
Larynx Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine whether aggressive acid suppression with Lansoprazole is effective in the treatment of post nasal drip, and also assess the predictors of response based on cl...
Detailed Description
Postnasal drip (PND) is a common complaint that brings patients to the attention of their primary care physicians. It is also one of the most common reasons for patients to seek care from otolaryngolo...
Eligibility Criteria
Inclusion
- Negative RAST inhalant allergy panel OR negative skin testing (Group A)
- Positive RAST or Positive skin testing AND insufficient response to all of the following: (Group B)
- Allergen avoidance
- Topical nasal steroids
- Allergy shots if indicated
- Antihistamines
- Negative CT sinuses (coronal)
- \< 4mm of mucosal thickening and \< 3 sinus sites
- Absence of air-fluid levels
- Negative anterior rhinoscopy
- Absence of pus, crusts on mucosal surfaces
Exclusion
- Age \< 18
- Pregnancy, confirmed by urine pregnancy test at day of randomization
- Ciliary dyskinesia
- Immune deficiency
- Cystic fibrosis
- Diagnosis of acute sinusitis or chronic RS (AAO-HNS)
- Active use of topical decongestant
- Use of PPI within the last 30 days
- Previous fundoplication
- Uncontrolled thyroid disease
- Isolated chronic cough without the symptom of post nasal drip
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00335283
Start Date
August 1 2006
End Date
December 1 2008
Last Update
August 21 2012
Active Locations (1)
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1
Vanderbilt University Medical Center, Vanderbilt Digestive Disease Clinic, TVC, Room 1660
Nashville, Tennessee, United States, 37232-5280