Status:
COMPLETED
Predictive Medicine Research. (PRE MED)
Lead Sponsor:
Emory University
Collaborating Sponsors:
The Robert W. Woodruff Foundation
Conditions:
Cardiovascular Diseases
Eligibility:
All Genders
30-90 years
Brief Summary
Principal Investigator: Arshed A. Quyyumi, MD To establish normal values by age, race, and gender of novel markers of risk in healthy subjects necessary to predict precise risk of cardiovascular dise...
Detailed Description
Introduction: As a person ages their chance of developing certain diseases such as hardening of the arteries (atherosclerosis), diabetes, depression, osteoporosis and memory loss (Alzheimer's disease...
Eligibility Criteria
Inclusion
- Ages 30-90.
- Healthy normal performance status.
- LDL cholesterol level \<120 mg/dl
- Fasting blood glucose \<99 mg/dL
- Blood pressure \<135 mmHg systolic and \<85 mmHg diastolic
- Non-smoker for at least 5 years
- BMI \>19 and \<26; stable body weight
- Free of neurological and psychological (Axis I) disorders for at least three years.
Exclusion
- · Any oral antioxidants in the previous 2 weeks.
- On lipid lowering medication in the past 8 weeks.
- History of substance abuse.
- Current neoplasm or history of neoplasia except basal cell cancer.
- Any heart disease except for corrected congenital ht disease. History of neurological disease.
- History of chronic GI disorders.
- History of Rheumatologic disorders.
- Known endocrine disorders.
- History of Chronic Pulmonary diseases eg. COPD
- Acute illness such as infection in the previous 4 weeks.
- Creatinine \> 2
- Liver enzymes \>1.5X normal.
- Anemia (Hb \< 12.5) or chronic hematological disorder.
- Physical limitation and sedentary status for any reason.
- LDL cholesterol\>120.
- Fasting Glucose\>99.
- BP \>135/85 on 3 repeated measures.
- Current smoker or smoker in the last 5 years.
- History of depression.
- Inability to give informed consent.
- Age \<30
Key Trial Info
Start Date :
February 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
288 Patients enrolled
Trial Details
Trial ID
NCT00336570
Start Date
February 1 2006
End Date
October 1 2010
Last Update
November 18 2013
Active Locations (1)
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1
Emory University Hospital
Atlanta, Georgia, United States, 30322