Status:
WITHDRAWN
Study to Improve Scientific Understanding of the Cardiovascular Actions of Cocaine
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Induced Sympathoexciation and Vasoconstriction
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to improve the scientific understanding of the cardiovascular actions of cocaine, in particular the ability of cocaine to increase blood pressure.
Detailed Description
Cocaine abuse has emerged as a major cause of life-threatening cardiovascular emergencies but our understanding of the underlying mechanisms mediating the adverse effects of cocaine is far from comple...
Eligibility Criteria
Inclusion
- Cocaine naive healthy volunteers
Exclusion
- Any evidence of cardiopulmonary disease by history or physical examination
- History of hypertension or 24 hour blood pressure averaging \>135/85 mmHg
- Any history of substance abuse (other than tobacco)
- Diabetes mellitus or other systemic illness
- Individuals with a history of pseudocholinesterase deficiency
- Pregnancy
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00338546
Last Update
January 16 2019
Active Locations (1)
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1
Univ of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390