Status:
COMPLETED
Effect of Exercise and Diet on Inflammation in Hypertensive Individuals
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Hypertension
Eligibility:
All Genders
25-60 years
Phase:
NA
Brief Summary
In addition to high blood pressure, hypertension is characterized by inflammation, which is the body's response to injury or infection. Inflammation has been found to cause plaque formation on artery ...
Detailed Description
Hypertension is characterized by high blood pressure, as well as by inflammation and increased adhesion among blood cells. Inflammation may play an important role in atherosclerosis, which involves th...
Eligibility Criteria
Inclusion
- Unmedicated hypertension with blood pressure greater than 140/90 mm Hg but less than 175/104 mm Hg
- Body mass index (BMI) of 23.5 to 34
- Relatively inactive, as defined by the Leisure Time Exercise Questionnaire
- Willing and able to participate in the assigned study group
- Postmenopausal women not on hormone replacement therapy (HRT) and premenopausal women
Exclusion
- Abnormal echocardiogram
- Recent stroke or significant brain impairment
- Current psychiatric disease
- History of psychosis or major depression
- Currently taking psychotropic drugs
- Currently taking any medications (e.g., anti-inflammatory medications) other than antihypertensives (which will be tapered)
- Current drug and/or alcohol abuse
- Consumes more than 600 mg of caffeine per day
- Diabetes
- Congestive heart failure
- Bronchospastic pulmonary disease
- History of heart attacks
- Known secondary high blood pressure
- Angina
- History of life-threatening arrhythmias
- History of kidney damage
- Current participation in regular or structured exercise classes, or regular physical exercise in the 6 months prior to study entry
- Inability to perform moderate to vigorous intensity exercise
- Current participation in a diet
- High blood pressure, only when measured in a doctor's office (i.e., "white coat hypertension")
- Arthritis, exertional asthma, or any other disorder likely to be made worse by exercise
- Pregnant
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
185 Patients enrolled
Trial Details
Trial ID
NCT00338572
Start Date
June 1 2006
End Date
April 1 2012
Last Update
June 8 2012
Active Locations (1)
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1
University of California, San Diego
San Diego, California, United States, 92103