Status:
UNKNOWN
Aortic Stenosis in Elderly : Determinant of Progression
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Aortic Stenosis
Elderly Gravida
Eligibility:
All Genders
70+ years
Brief Summary
Aortic stenosis (AS) is AS is caused by calcium deposits in the aortic valve. Calcification is progressive and eventually leads to reduced leaflet motion with obstruction of the left ventricular outfl...
Detailed Description
Aortic stenosis (AS) is the most common valvular disease and the second most common indication for cardiac surgery in Western countries. AS prevalence increases with age and with aging of the populati...
Eligibility Criteria
Inclusion
- Age ≥ 70 years
- AS with mean transmitral gradient \> 10 mm Hg and aortic valve area \< 2 cm2
- No surgical indication
Exclusion
- Rheumatic or congenital AS
- Associated valvular disease grade ≥ 2/4
- Indication for surgery (severe AS (aortic valve area \< 1 cm2 or \< 0.6 cm2/m2 of body surface area and symptoms or congestive heart failure or left ventricular ejection fraction \< 50%)
- Renal insufficiency (creatinine clearance \< 30 ml /min)
- Left ventricular outflow tract obstruction
Key Trial Info
Start Date :
November 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2017
Estimated Enrollment :
273 Patients enrolled
Trial Details
Trial ID
NCT00338676
Start Date
November 1 2006
End Date
September 1 2017
Last Update
March 1 2017
Active Locations (1)
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1
Hopital Bichat
Paris, France, 75018