Status:
COMPLETED
Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
HIV Infections
Depression
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally ...
Detailed Description
Antiretroviral drug therapy (ART) is a type of medication treatment for HIV that impairs the virus's ability to multiply. When used properly, it has been shown to be successful in reducing HIV-related...
Eligibility Criteria
Inclusion
- Homeless or marginally housed
- Score of greater than 13 on the Beck Depression Inventory (BDI)
- DSM-IV diagnosis of major depressive disorder, dysthymia, or minor depressive disorder
- Considered by the reviewing psychiatrist to benefit from antidepressant therapy
- Willing to take antidepressant medication or, if currently taking medication, willing to change medications if deemed appropriate
- Consents to coordinate with the primary medical provider
- Speaks English
Exclusion
- Signs and symptoms consistent with diagnosis of dementia, as defined by DSM-IV
- Current substance abuse disorder requiring immediate residential or inpatient treatment
- At risk for suicide
- Presence of signs and symptoms consistent with psychotic depression, as defined by DSM-IV, warranting immediate hospitalization
- Any condition or use of any medication that may make simultaneous use of antidepressant medication unsafe
- Currently prescribed antidepressant therapy and in psychiatric treatment (treated by a psychiatrist within 3 months prior to study entry)
- Pregnant
- Bipolar disorder
- Current psychotic disorder
Key Trial Info
Start Date :
January 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2006
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00338767
Start Date
January 1 2001
End Date
August 1 2006
Last Update
November 15 2013
Active Locations (1)
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1
UCSF Market Street Study Site
San Francisco, California, United States, 94102