Status:
COMPLETED
Effect of Albendazole Dose on Clearance of Filarial Worms
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Lymphatic Filariasis
Eligibility:
All Genders
14-65 years
Phase:
PHASE2
Brief Summary
This study, conducted in Mali, West Africa, will determine whether a new treatment regimen for lymphatic filariasis can eliminate the disease more quickly than the standard regimen. Lymphatic filarias...
Detailed Description
Albendazole and ivermectin are currently used in combination for annual mass treatment of lymphatic filariasis in Africa. Although the drugs have been donated, the cost of such programs is very high a...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA (Screening):
- age 14 to 65.
- men and women\*.
- Please note: women are not permitted to leave their homes at night without the approval of their husband or, if they are not married, a parent or male guardian. Since this protocol involves blood drawing at night, such approval is necessary for participation.
- EXCLUSION CRITERIA (Screening):
- non-volunteers.
- age less than 14 or greater than 65.
- pregnant by history.
- INCLUSION CRITERIA (Treatment):
- age 14 to 65 years.
- men and women.\*
- Wb microfilarial count greater than or equal to 50 mf/ml.
- EXCLUSION CRITERIA (Treatment):
- non-volunteers.
- age less than 14 or greater than 65.
- pregnancy.
- Hgb less than 9 g/dl.
- Heavy alcohol use (more than 7 beer or other alcohol-containing drink/week).
- Temperature greater than 37.5C or other serious medical illnesses.
- history of benzimidazole allergy.
- history of ivermectin allergy.
- use of albendazole or ivermectin within the past 6 months.
Exclusion
Key Trial Info
Start Date :
February 22 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 17 2011
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT00339417
Start Date
February 22 2006
End Date
August 17 2011
Last Update
July 2 2017
Active Locations (1)
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1
University of Bamako, Faculty of Medicine, Pharmacy and Odontostomatology
Bamako, Mali