Status:
COMPLETED
DNA Repair, p53 and Apoptosis Phenotypes in Lung Cancer
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Lung Neoplasms
Eligibility:
All Genders
18-90 years
Brief Summary
The Laboratory of Human Carcinogenesis and the Pharmocogenetics Section of the Genetic Epidemiology Branch will conduct a lung cancer case-control study in Baltimore, Maryland. The primary hypothesis ...
Detailed Description
Background: The Laboratory of Human Carcinogenesis is conducting an observational non-small cell lung cancer (NSCLC) case-control study in Baltimore, MD. This molecular epidemiology study was develop...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Case Subject Selection:
- Diagnosis of non-small cell lung cancer made pathologically (with confirmation by a second pathologist).
- Must reside in Baltimore city or contiguous metropolitan counties, Prince George's county or Anne Arundel county.
- Have a residential working phone within their home.
- Be born in the United States.
- Speak English well enough to be interviewed.
- Be physically and mentally capable of performing the interview (i.e., must be able to hear the interviewer, mentally comprehend the interviewers questions and verbally respond).
- Never have been interviewed as a control for the study.
- Consent by the physician from the clinic where the subject was identified, or listed as the treating physician by the tumor registry or surgical pathology report.
- Report of a positive LDCT screen by a physician
- Hospital-Based Control Selection:
- Stratified to frequency match cases by age (5 year intervals), gender, race, smoking (20 pack year intervals -- non-smokers, 0-20, 20-40, 40-60 and greater than 60 and ex-smokers \[greater than 5 yrs\]) and hospital.
- Must reside in Baltimore city, contiguous metropolitan counties, Prince George's county or Anne Arundel county.
- Have a residential working phone within their home.
- Be born in the United States.
- Speak English well enough to be interviewed.
- Be physically and mentally capable of performing the interview (i.e., must be able to hear the interviewer, mentally comprehend the interviewers questions and verbally respond).
- Never have been interviewed as a control for the study.
- Physician consent by physician from clinic with subject is identified.
- Selection of Population-Based Controls:
- Stratified to match cases by age (5 year intervals), gender, and race.
- Must reside in Maryland
- Have a residential working phone within their home.
- Be born in the United States.
- Speak English well enough to be interviewed.
- Be physically and mentally capable of performing the interview (i.e., must be able to hear the interviewer, mentally comprehend the interviewers' questions and verbally respond).
- Never been interviewed as a control for the study.
- EXCLUSION CRITERIA:
- Case Subject Selection:
- More than 6 months after initial diagnosis.
- Currently residing in an institution such as prison, nursing home or shelter.
- Severely ill in an intensive care unit (after discharge from ICU, then can be reconsidered).
- Subjects is unable to give informed consent.
- Hospital-Based Control Selection:
- History of cancer other than non-melanotic skin cancer or in situ cervical cancer.
- Currently residing in an institution such as a prison, nursing home or shelter.
- Severely ill in an intensive care unit (after discharge from ICU, the can be reconsidered).
- Subject is unable to give informed consent.
- Known diagnosis of HIV, hepatitis B or C.
- Selection of Population-Based Controls:
- History of cancer other than non-melanotic skin cancer or in situ cervical cancer.
- Currently residing in an institution such as a prison, nursing home or shelter.
- Subjects unable to give informed consent.
Exclusion
Key Trial Info
Start Date :
June 2 1995
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 6 2020
Estimated Enrollment :
5625 Patients enrolled
Trial Details
Trial ID
NCT00339859
Start Date
June 2 1995
End Date
May 6 2020
Last Update
May 11 2020
Active Locations (2)
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1
University of Maryland, Baltimore
Baltimore, Maryland, United States, 21201-1595
2
VA Hospital, Baltimore
Baltimore, Maryland, United States, 21201