Status:
COMPLETED
Influence of Genetics on Vitamin Metabolism in Pregnant Women
Lead Sponsor:
National Human Genome Research Institute (NHGRI)
Conditions:
Pregnancy
Birth Defects
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine how the body metabolizes micronutrients, such vitamins, during pregnancy and how genetic make-up influences their metabolism. Vitamin B12 and folate levels in pregnancy have be...
Detailed Description
A number of genetic polymorphisms influence human folate, vitamin B12 and related micronutrient levels. Vitamin B12 and folate levels in pregnancy have been linked to birth defects including neural tu...
Eligibility Criteria
Inclusion
- Eligible participants will be women of Irish origin (older than 18) presenting for prenatal care to the Coombe Women's Hospital, Dublin, Republic of Ireland. Non-Irish women (a small proportion of the population) will be excluded because the prevalence of genetic polymorphisms can vary greatly among different populations; we already have an estimate of the distribution of this genotype in the Irish women. Members of the only minority group native to Ireland, the Travelers, will not be excluded. While culturally distinct, the Travelers are genetically similar to the majority population. Women with multiple pregnancy (more than one fetus) and users of IV drugs will be excluded. Women will be asked for permission to obtain a cord blood sample from the infant at delivery. Women will be asked to assist with recruitment of their partners (father of the fetus), who will be included if they consent.
Exclusion
Key Trial Info
Start Date :
December 16 2003
Trial Type :
OBSERVATIONAL
End Date :
December 10 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00340366
Start Date
December 16 2003
End Date
December 10 2007
Last Update
July 2 2017
Active Locations (1)
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1
The Coombe Maternity Hospital
Dublin, Ireland