Status:
TERMINATED
Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population
Lead Sponsor:
National Human Genome Research Institute (NHGRI)
Conditions:
Neural Tube Defects (NTDs)
Facial Cleft Defect
Eligibility:
All Genders
Up to 85 years
Brief Summary
In a collaborative effort with the Health Research Board, the national organization for medical research in the Republic of Ireland, individuals with neural tube defects (NTDs) or facial cleft defects...
Detailed Description
In a collaborative effort with the Health Research Board, the national organization for medical research in the Republic of Ireland, individuals with neural tube defects (NTDs) or facial cleft defects...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Eligible participants are children and adults with an NTD and their parents residing in the Republic of Ireland, Northern Ireland and the United Kingdom
- NTDs are defined to include all forms of spina bifida aperta (meningocele, meningomyelocele), encephalocele, anencephaly, rachischisis, iniencephaly and lipomeningocele. Hydrocephalus, hydranencephaly, dermal sinus and spina bifida occulta do not qualify as NTDs.
- For oral clefts, eligible participants are children and adults with a facial cleft in Ireland and their parents.
- All families with NTDs or clefts will be recruited for the study.
- EXCLUSION CRITERIA:
- Those with known syndromes will be excluded or analyzed separately.
- Cases for whom both biologic parents are not available will be excluded from some components of triad (case, mother and father) analysis, although the data from the NTD case may be useful for other study components.
Exclusion
Key Trial Info
Start Date :
January 1 2000
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 2 2019
Estimated Enrollment :
7451 Patients enrolled
Trial Details
Trial ID
NCT00341068
Start Date
January 1 2000
End Date
December 2 2019
Last Update
December 5 2019
Active Locations (1)
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1
National Human Genome Research Institute (NHGRI), 9000 Rockville Pike
Bethesda, Maryland, United States, 20892