Status:
COMPLETED
Genetic Causes of Male Infertility
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Male Infertility
Eligibility:
MALE
20-45 years
Brief Summary
This study is being conducted at the University Hospital of Lund University in Malmo, Sweden, in collaboration with the U.S. National Institute of Child Health and Human Development. The study will tr...
Detailed Description
It is evident that genetic variation plays a substantial role in the etiology of male infertility. Studies of children fathered through intracytoplasmic sperm injection or ICSI have revealed mutations...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA INFERTILE MEN:
- Referred to the Scanian Andrology Centre.
- Age 20-45.
- Partner age less than 40.
- Having had regular sexual intercourse without contraception for a year or more without achieving a pregnancy.
- EXCLUSION CRITERIA INFERTILE MEN:
- Klinefelters syndrome.
- Hypogondotropic hypogonadism.
- Y-chromosome microdeletion or abnormality.
- Other genetic cause for infertility.
- Obstructive azoospermia.
- Partner with salpingitis.
- Partner with polycystic ovarian syndrome.
- Partner with disturbance of ovulation.
- Partner with endometriosis.
- History of cancer.
- History of treatment with cytotoxic drugs, irradiation, or sulfasalazopyrine.
- History of cryptorchidism.
- History of mumps orchitis.
- History of vasectomy.
- INCLUSION CRITERIA FERTILE MEN:
- Partner attending Lund University prenatal clinic.
- Age 20-45.
- Partner age less than 40.
- Having fathered one or more pregnancies.
- Having stopped birth control to achieve present pregnancy.
- Having achieved present pregnancy in less than 12 months of unprotected intercourse.
- EXCLUSION CRITERIA FERTILE MEN:
- History of cancer.
- History of treatment with cytotoxic drugs, irradiation, or sulfasalazopyrine.
- History of cryptorchidism.
- History of mumps orchitis.
- Having sought or partner having sought treatment or investigation for fertility.
Exclusion
Key Trial Info
Start Date :
January 2 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 29 2012
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT00341120
Start Date
January 2 2003
End Date
August 29 2012
Last Update
April 5 2018
Active Locations (1)
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1
Malmo University Hospital
Malmo, Sweden