Status:
COMPLETED
Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Malaria
Filarial Infection
Eligibility:
All Genders
1-65 years
Brief Summary
This study, conducted by NIH and the University of Bamako in Mali, Africa, will study the effect of concurrent infections with malaria and filariasis on patients' immune response. Lymphatic filariasis...
Detailed Description
Residents of malaria-endemic regions are frequently exposed to a variety of other parasites concurrently with malarial parasites. In Mali, lymphatic filariasis co-exists in several regions highly ende...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age 1-8 years or age 18-65 years.
- Either resident of N'Tessoni (for active cohort) or resident of Bamako (for control cohort).
- EXCLUSION CRITERIA:
- Pregnancy (for the adult cohort).
- Hemoglobin less than or equal to 8g/dl.
- Symptoms of malaria with any level of parasitemia.
- Recent history or clinical evidence of prostration, bleeding, respiratory distress, seizures, coma or obtundation, jaundice, inability to drink, persistent vomiting.
- History of allergy to sulfa or pyrimethamine-sulfadoxine.
- Plans to relocate outside the immediate village vicinity during the study period.
- Clinical evidence of severe and/or chronic illness as determined by the examining physician.
Exclusion
Key Trial Info
Start Date :
April 3 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 15 2011
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT00341666
Start Date
April 3 2006
End Date
July 15 2011
Last Update
July 2 2017
Active Locations (1)
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1
University of Bamako, Faculty of Medicine, Pharmacy and Odontostomatology
Bamako, Mali