Status:
COMPLETED
Functional Neuroimaging in Depression
Lead Sponsor:
University Hospital, Ghent
Collaborating Sponsors:
Fund for Scientific Research, Flanders, Belgium
H. Lundbeck A/S
Conditions:
Major Depression
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Oral administration of escitalopram during 8 weeks; PET scan with 18F-FDG at inclusion and after 8 weeks
Eligibility Criteria
Inclusion
- Major Depression, Depressive episode, following DSM-IV criteria
- MADRS-score \> 25
- Age: 18-65 yrs
- Medication-free or anti-depressant wash-out 7 days (for fluoxetine: 6 weeks)
- Lorazepam 1mg or zolpidem 10mg are allowed
Exclusion
- Suicidality
- Bipolar disorder, following DSM-IV criteria
- Psychotic symptoms
- Substance abuse
- Personality disorder, following DSM-IV criteria
- Cognitive dysfunction due to trauma capitis or dementia
- Diabetes mellitus
- Women without contraceptive protection, with pregnancy or breast feeding
- Pharmacological treatment or ingestion of substance that can influence cerebral perfusion less than a month before inclusion
- IQ below 80
- Conditions not compatible with SPC
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00343070
Start Date
March 1 2007
End Date
October 1 2009
Last Update
August 31 2010
Active Locations (2)
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1
University Hospital Ghent
Ghent, Belgium, 9000
2
AZ Groeninge campus Sint Maarten
Kortrijk, Belgium, 8500