Status:
COMPLETED
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Essential Hypertension
Lead Sponsor:
Regional Hospital Holstebro
Conditions:
Essential Hypertension and Healthy Controls
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of the study is to test the following hypotheses: * that the function and/or regulation of AQP2 and/or ENaC in the principal cells is abnormal in essential hypertension. * if an abnormal func...
Eligibility Criteria
Inclusion
- Caucasian men and women
- Age 18-65 years
- Arterial hypertension
- Body mass index between 18.5 and 30 kg/m2
Exclusion
- Secondary hypertension
- Isolated systolic hypertension
- History or clinical signs of AMI, atrial fibrillation, disease of the heart valves, or chronic heart failure.
- Malignant disease
- Prior apoplexy
- alcohol or drug abuse
- Drug use except antihypertensives and oral contraceptives
- Abnormal biochemical screening of the blood regarding: red and white blood count, s-creatinine (\> 200 micromol/L), b-hemoglobin, p-Sodium, p- potassium, p-albumine, p-bilirubin, p-alanine aminotransferase, p-alkaline phosphatase, p-cholesterol and b-glucose.
- Abnormal screening of the urine regarding: Blood, albumine and glucose.
- abnormal electrocardiogram
- Blood donation within one month of the first examination day
- Unwillingness to participate
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00345124
Start Date
May 1 2006
End Date
August 1 2009
Last Update
June 28 2011
Active Locations (1)
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1
Department of Medical Research, Holstebro Hospital
Holstebro, Denmark, 7500