Status:
SUSPENDED
Transplantation of Cultivated Limbal Epithelium on Amniotic Membrane for Limbal Stem Cell Deficiency
Lead Sponsor:
Singapore National Eye Centre
Collaborating Sponsors:
Singapore Eye Research Institute
Conditions:
Ocular Surface Disease
Eligibility:
All Genders
Phase:
PHASE2
Brief Summary
To evaluate the effectiveness of autologous (tissue from fellow eye) transplantation of cultivated limbal epithelium on amniotic membrane to treat severe surface irregularity and scarring of the corne...
Detailed Description
The corneal epithelium is under constant cell-turnover,and it has been shown that the limbus is the ultimate source of epithelial renewal. Significant damage to limbal cells causes a disease state cal...
Eligibility Criteria
Inclusion
- unilateral total limbal stem cell deficiency with normal fellow eye, or minimally damaged fellow eye (less than 1/3 limbus affected)
Exclusion
- systemic disease affecting both eyes such as Stevens-Johnson syndrome
Key Trial Info
Start Date :
May 1 2002
Trial Type :
INTERVENTIONAL
End Date :
May 1 2006
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00348114
Start Date
May 1 2002
End Date
May 1 2006
Last Update
July 4 2006
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