Status:
COMPLETED
Bronchodilators and Oxygen Kinetics With Exercise in Chronic Obstructive Pulmonary Disease (COPD) Patients
Lead Sponsor:
Queen's University
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40-80 years
Phase:
PHASE4
Brief Summary
Hypothesis: The reduction of dynamic hyperinflation and its negative effects on the respiratory system following a bronchodilator could lead to an improvement of cardiac function in terms of increased...
Detailed Description
The inability to engage in the usual activities of daily living is one of the most distressing experiences of people afflicted with Chronic Obstructive Pulmonary Disease (COPD). Exercise intolerance p...
Eligibility Criteria
Inclusion
- 40-80 years
- stable COPD
- FEV1 \< 60 % predicted
- severe chronic breathlessness (Baseline Dyspnea Index \< 6)
Exclusion
- SpO2 at rest \< 90% or a a sustained decrease of \> 4% in arterial O2 saturation during the ergometer test, as determined by pulse oximetry
- a body mass index (BMI) \< 19 or \> 30
- chronic oral steroid therapy
- other medical conditions which could cause or contribute to breathlessness, i.e., heart disease or other respiratory diseases
- other problem which could interfere with carrying out of exercise testing, i.e., neuromuscular diseases, orthopedic diseases, etc.
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00354354
Start Date
March 1 2006
End Date
July 1 2009
Last Update
April 19 2011
Active Locations (1)
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1
Respiratory Investigation Unit (Queen's University)
Kingston, Ontario, Canada, K7L 2V7