Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients

Status:

COMPLETED

Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients

Lead Sponsor:

Dr. Josip Benčević General Hospital

Collaborating Sponsors:

University of Zagreb

Conditions:

Respiratory Failure

Eligibility:

All Genders

18+ years

Phase:

PHASE4

Brief Summary

To evaluate and compare two methods of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease (COPD) where the extubation failed.

Detailed Description

A prospective, randomized trial was performed in a multidisciplinary Intensive Care Unit (ICU) for the duration of 2 years. A total of 136 COPD patients who required mechanical ventilation longer than...

Eligibility Criteria

Inclusion

COPD
exacerbation of dyspnea \<2 weeks
signs of respiratory muscle dysfunction

Exclusion

non COPD patients
age \<18 years
tracheotomy
MV duration shorter than 24h
use of MV on admission to the ICU or transfer to some other ICU for treatment continuation
patients who died or weaning from MV was discontinued because of another associated disorder
central nerve system disorders unrelated to hypercapnic encephalopathy or hypoxemia
cardiac arrest within 5 days
patients scheduled for organ donation

Key Trial Info

Start Date :

Trial Type :

INTERVENTIONAL

End Date :

Estimated Enrollment :

Patients enrolled

Trial Details

Trial ID

NCT00355732

Last Update

October 26 2006

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