Status:
COMPLETED
Growth Hormone as a Determinant of Weight Regulation
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
With the alarming increase in the prevalence of obesity, identifying factors that predispose individuals to weight-gain is of critical importance. Even when caloric intake and physical activity levels...
Detailed Description
The susceptibility to gain weight is highly variable even when caloric intake and physical activity are well controlled. Because basal metabolic rate (BMR) represents \~70% of total daily energy expen...
Eligibility Criteria
Inclusion
- Age = 21-35 years Weight stable (\< ± 5 pound over past 6 months) Premenopausal (women only) Body mass index 18 - 26 kg/m2 Must be willing to be randomized to receive GH infusion during 2 week Michigan Clinical Research Unit (MCRU) visit
Exclusion
- Evidence of metabolic or cardiovascular disease Pregnancy (women only) Hyperlipidemia (fasting plasma triglyceride concentration \> 150 mg/dl) Hematocrit \< 34% Liver Function test abnormalities participating in a regular exercise program (\> 2 h/week) taking any prescription medication (except birth control)
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00355784
Start Date
September 1 2005
End Date
December 1 2015
Last Update
January 1 2016
Active Locations (1)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48109