Status:
COMPLETED
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients
Lead Sponsor:
CHU de Charleroi
Conditions:
Ascitic Cirrhosis
Hyperactivation of Sympathetic Nervous System
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense asc...
Eligibility Criteria
Inclusion
- Cirrhotic patients with ascites
- Plasma norepinephrine level \> 300 pg/mL (normal value: 185 - 275 pg/mL)
Exclusion
- Serum bilirubin concentration above 4.5 mg/dL
- Prothrombin time below 40%
- Platelet count below 40 X 10¨9/liter
- Serum creatinine concentration above 2 mg/dL
- Gastro-intestinal hemorrhage
- Alcoholic hepatitis
- Diabetes mellitus,
- Hepatocellular carcinoma
- Respiratory or cardiac failures
- Hepatic encephalopathy
- Bacterial infection
Key Trial Info
Start Date :
October 1 2000
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00356226
Start Date
October 1 2000
Last Update
December 4 2006
Active Locations (1)
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1
ISPPC CHU de Charleroi
Charleroi, Belgium, 6000