Status:
COMPLETED
Effects of Atorvastatin on Disease Activity and HDL Cholesterol Function in Patients With Rheumatoid Arthritis
Lead Sponsor:
University of California, Los Angeles
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This research evaluates the effects of a cholesterol-lowering medication, atorvastatin, on both arthritis activity and the ability of high-density lipoprotein cholesterol (HDL-C, sometimes referred to...
Detailed Description
Heart attacks are the leading cause of death in patients with rheumatoid arthritis (RA). Cardiovascular events occur more frequently than would be expected in patients with RA and traditional heart ri...
Eligibility Criteria
Inclusion
- Fulfill American College of Rheumatology (ACR) criteria for RA
- At least 18 years of age
- Have RA for at least one year with ongoing active disease (active disease defined as at least two of three: 1) ≥ six tender joints; 2) ≥ three swollen joints; 3) ≥ 45 minutes of morning stiffness)
- Taking stable doses of disease modifying anti-rheumatic drug (DMARD) therapy for at least 3 months prior to study entry -
Exclusion
- Unable to give informed consent
- Pregnant or lactating
- Eligible for pharmacologic lipid-lowering therapy per National Cholesterol Treatment Program Adult Treatment Panel III guidelines
- Using any lipid lowering medication
- Known hepatic disease
- Elevated liver transaminase levels within the past two months
- Previous treatment in the last three months with hydroxychloroquine
- \-
Key Trial Info
Start Date :
March 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2005
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00356473
Start Date
March 1 2003
End Date
September 1 2005
Last Update
June 22 2012
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