Status:
COMPLETED
NASPI: N-Acetylcysteine vs. Ascorbic Acid for Prevention of Contrast Induced Nephropathy in Renal Insufficiency Undergoing Coronary Catheterization
Lead Sponsor:
Seoul National University Hospital
Conditions:
Kidney Failure
Eligibility:
All Genders
19+ years
Phase:
PHASE4
Brief Summary
The contrast induced nephropathy (CIN) has been known to be associated with significant clinical and economic consequences. Many studies were performed to find the pathophysiology and preventive measu...
Detailed Description
N-acetylcysteine and ascorbic acid may prevent the CIN in the patients with underlying renal insufficiency who is undergoing the coronary angiography. The effect may derive from the antioxidant functi...
Eligibility Criteria
Inclusion
- Stable Angina pectoris patients
- Patients who required the coronary catheterization
- Creatinine clearance rates =\<60 mL/min using the Cockcroft-Gault formula
- Age of 19 or over 19
Exclusion
- Pregnancy
- Lactation
- Having received contrast media within 7 days of study entry
- Emergent coronary angiography
- Acute renal failure
- End-stage renal disease requiring dialysis
- History of hypersensitivity reaction to contrast media
- Cardiogenic shock
- Pulmonary edema
- Multiple myeloma
- Mechanical ventilation
- Parenteral use of diuretics
- Recent use of N-acetylcysteine
- Recent use of Ascorbic acid
- Recent use of statin
- Use of metformin or nonsteroidal anti-inflammatory drugs within 48 hours of the procedure.
Key Trial Info
Start Date :
February 1 2005
Trial Type :
INTERVENTIONAL
End Date :
April 1 2006
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00356954
Start Date
February 1 2005
End Date
April 1 2006
Last Update
November 27 2006
Active Locations (1)
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1
Seoul National University Hospital , Cardiovascular Center
Seoul, South Korea