Status:
TERMINATED
Weaning From Mechanical Ventilation Using Permissive Hypercarbia
Lead Sponsor:
Milton S. Hershey Medical Center
Conditions:
Respiration, Artificial
Respiratory Distress Syndrome, Adult
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Some patients receiving mechanical ventilation have difficulty weaning off the ventilator because of physiological factors such as pre-existing lung disease, respiratory distress syndrome, and trauma ...
Detailed Description
The primary objective of this research is to assess the utility of permissive hypercarbia (PH) in the weaning of patients with risk factors for difficult weaning from mechanical ventilation. This pilo...
Eligibility Criteria
Inclusion
- Adult (\> 18 yo) patients in the intensive care units at the Hershey Medical Center who are on mechanical ventilation
- and whose clinical course permits weaning from mechanical ventilation
- and are felt to have risk factors for difficult weaning. (Risk factors will include patients with rib fractures, pulmonary contusions, obesity (BMI \>30), or history of COPD or other significant lung disease.)
- all patients will have failed (rapid shallow breathing index \>105) a 30 minute spontaneous breathing test.
Exclusion
- Overt signs of sepsis including: a temperature \> 38.5F, white blood cell count \> 14000, systolic blood pressure \< 100 mmHg,
- intracranial hypertension (ICP \> 18 or based upon clinical exam and/or history),
- or pulmonary hypertension (by history or PAsys \> 40 mmHg).
- or history of recent(past 6 mos)MI
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 14 2007
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT00357929
Start Date
August 1 2006
End Date
June 14 2007
Last Update
October 20 2017
Active Locations (1)
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1
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033