Status:
COMPLETED
Genetic Studies of X-linked Lymphoproliferative Disease
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
X-Linked Lymphoproliferative Disease
Lymphoproliferative Disease
Eligibility:
All Genders
Brief Summary
This study will study the effects of the gene on the X chromosome that is associated with X-linked lymphoproliferative disease (XLPD)-an inherited disease affecting the immune system-on the function o...
Detailed Description
Males with the X-linked ymphoproliferative disease (XLPD) have a marked susceptibility to Epstein-Barr virus (EBV) disease. These boys develop very severe disease associated with infectious mononucleo...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients known to have XLPD and their relatives will be recruited from families who have enrolled in a national XLPD registry.
- All racial and ethnic groups will be considered.
- To be considered having XLPD, a patient must be a male who has had:
- severe infectious mononucleosis, or
- acquired hypogammaglobulinemia following infectious mononucleosis, or
- nonHodgkin's lymphoma, or
- hyper-IgM or an IgG subclass deficiency with evidence of linkage to the DXS42 locus
- and
- have no other known immunocompromising condition and belong to a family in which another related male has had one or more of the above listed phenotypes.
- EXCLUSION CRITERIA:
- Known HIV infection in any patient with XLPD or their relative (blood will not be tested for HIV), complicating medical or psychiatric conditions in unrelated controls.
Exclusion
Key Trial Info
Start Date :
May 22 1996
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00359411
Start Date
May 22 1996
End Date
February 1 2010
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892