Status:
TERMINATED
Treatment With MK6592 and an Anti-cancer Drug in Patients With Advanced Solid Tumors (6592-001)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Advanced Solid Tumors
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
A study to evaluate safety and tolerability of MK6592 in combination with an anti-cancer drug in adult patients with advanced solid tumors.
Eligibility Criteria
Inclusion
- Patients with advanced solid tumors (metastatic or local) unresponsive to standard therapy, progressed on standard therapy, or no standard therapy exists. No limit to the number of prior treatment regimens
- Patients may be fully active without physical restrictions, ambulatory with restrictions on strenuous physical activity, or ambulatory and capable of self-care but not work activities (i.e., Eastern Cooperative Oncology Group performance status of greater than or equal to 2)
- Demonstrates adequate organ function (liver, kidneys, hematologic)
Exclusion
- Chemotherapy or radiation therapy within 2 weeks of dosing; or unresolved side effects(s) from prior treatment regimen
- Participation in an investigational study within 14 days of dosing
- Primary central nervous system tumor
- Active brain or spinal cord metastases. Patients who completed a course of therapy for CNS metastases may be eligible if considered clinically stable for 3 months prior to study entry
- Symptoms from fluid in the abdomen or around the lungs
- Requires certain drugs or other products known to be metabolized by the liver enzyme CYP3A4
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2007
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT00359671
Start Date
December 1 2006
End Date
July 1 2007
Last Update
November 29 2016
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