Status:
COMPLETED
Does a Migraine Medication Decrease Rotational Motion Sickness in People Suffering From Migraines?
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Migraine
Eligibility:
All Genders
21-45 years
Phase:
NA
Brief Summary
The purpose of this study is to determine if Rizatriptan, a migraine medication, lowers motion sickness in migraine sufferers.
Detailed Description
Migraine sufferers undergo vestibular tests and were excluded if there were clinically significant abnormalities. Following screening, there were 2 experimental visits in which migraine sufferers were...
Eligibility Criteria
Inclusion
- History of motion sickness
- Currently suffering from migraines with at least 2 episodes during the previous 12 months
- Previous use and tolerance to triptans
Exclusion
- Current tobacco user
- History of or current hypertension, cardiac disease, arrhythmia, hypercholesterolemia, hemiplegic/basilar migraine, stroke, diabetes, vascular disease or kidney disease
- Family history of early myocardial infarction (first-degree relative \< 45 years old at time of event)
- Constant dizziness or constant vestibular symptoms
- History of ear, nose and throat (ENT) disease, e.g. Meniere's disease
- Current treatment with propranolol or medications that would preclude use of a triptan(e.g. ergotamine)
- Major vestibular abnormality found on screening
- Testing positive on over-the-counter pregnancy test
- Taken an Monamine Oxidase (MAO) inhibitor within two weeks of testing
- Allergy or intolerance to gelatin
- Corrected visual acuity of \> 20/40 O.U.
- Women who are pregnant or breastfeeding
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00360282
Start Date
August 1 2006
End Date
March 1 2010
Last Update
December 8 2014
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213