Status:
UNKNOWN
Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye
Lead Sponsor:
Children's Cancer and Leukaemia Group
Conditions:
Retinoblastoma
Eligibility:
All Genders
Up to 15 years
Phase:
NA
Brief Summary
RATIONALE: Drugs used in chemotherapy, such as carboplatin, vincristine, etoposide, and cytarabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping...
Detailed Description
OBJECTIVES: * Compare outcome data in children with advanced unilateral retinoblastoma with historical controls in order to determine whether post-enucleation chemotherapy with or without radiotherap...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed unilateral retinoblastoma
- Prior primary enucleation required
- No metastatic spread
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior chemotherapy
- No concurrent steroids as antiemetic agents
Exclusion
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00360750
Start Date
September 1 2005
Last Update
September 17 2013
Active Locations (13)
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1
Birmingham Children's Hospital
Birmingham, England, United Kingdom, B4 6NH
2
Institute of Child Health at University of Bristol
Bristol, England, United Kingdom, BS2 8AE
3
Addenbrooke's Hospital
Cambridge, England, United Kingdom, CB2 2QQ
4
Leeds Cancer Centre at St. James's University Hospital
Leeds, England, United Kingdom, LS9 7TF