Status:
COMPLETED
Diagnostic Performance of Screening Tests for Cushing s Syndrome
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Cushing's Syndrome
Eligibility:
All Genders
18-100 years
Brief Summary
This study will test the accuracy of screening tests for Cushing s syndrome in overweight people with signs of the disorder. Cushing s syndrome is a rare disorder caused by excess production of the ho...
Detailed Description
Cushing's syndrome is a rare disorder characterized by a variety of clinical signs and symptoms that reflect chronic exposure to hypercortisolism such as obesity, hypertension, glucose intolerance, in...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients presenting for weight loss treatment at the GWUWMP
- Patients must have at least two of the signs and symptoms in Table 1 of the protocol, in addition to weight gain. If abdominal pain, backache and/or headache are present, only one of these symptoms can be used in any given patient, so that another feature must be present.
- Willing and able to be seen for up to 24 months
- Age 18-75
- EXCLUSION CRITERIA:
- Weight more than 350 pounds, the maximum weight for radiologist examination tables necessary for the evaluation of Cushing's Syndrome
- Renal failure, creatinine greater than 2.6, because of possible effects on dexamethasone metabolism
- Pregnancy, because it alters interpretation of adrenal function tests
- Current use of oral, inhaled or intranasal glucocorticoids or use within 30 days of study
- Other significant medical disorders that may complicate participation or interpretation of the results. For example, a patient with a collagen vascular disorder who has taken intermittent high dose glucocorticoids, and might need to do this again, might not be offered participation.
- Use of black licorice or chewing tobacco within two weeks of the study or anticipated use during the study
- Use of phenytoin, barbiturate, loperamide or opiates within two weeks of the study or anticipated chronic use during the study.
Exclusion
Key Trial Info
Start Date :
September 19 2002
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 30 2019
Estimated Enrollment :
471 Patients enrolled
Trial Details
Trial ID
NCT00361777
Start Date
September 19 2002
End Date
October 30 2019
Last Update
December 16 2019
Active Locations (2)
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1
GW University Medical Center GW Hospital Center
Washington D.C., District of Columbia, United States, 20037
2
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892