Status:
TERMINATED
Elucidation of Acid-Induced Pulmonary Inflammation
Lead Sponsor:
University of Utah
Conditions:
Gastroesophageal Reflux
Asthma
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
This study will evaluate how heartburn may lead to different types of inflammation in one's airways. Additionally, the study will determine whether aggressive treatment of heartburn results in improve...
Detailed Description
Currently, many Americans suffer from asthma. The exact mechanism by which airway inflammation leads to asthma symptoms has yet to be clearly explained. In previous studies, persons with asthma appear...
Eligibility Criteria
Inclusion
- chronic cough consistent with bronchoreactivity
- Gastroesophageal reflux
Exclusion
- Severe asthmatics who have been hospitalized within the last 6 months or who have required oral steroid use within the last 4 weeks
- Severe coronary artery disease
- Cigarette/cigar smoking within the last 6 months
- Documented allergies affecting the respiratory system
- Subjects with contraindications to pH/impedance probe
- Hemophilia
- Septal deviation
- Subjects with contraindications to bronchoscopy as outlined by the American Thoracic Society Guidelines
- Anticoagulation
- Pregnancy
- Incarcerated patients
- Current oral steroid use (may suppress levels of inflammation)
- Upper respiratory infection within the last 2 weeks
- Ongoing acid suppression with a proton pump inhibitor, however, patients may be included if they have discontinued their proton pump inhibitor within the last 1 month with stable asthma symptoms as defined by stable utilization of inhaled steroids
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT00361972
Start Date
August 1 2006
End Date
April 1 2009
Last Update
August 5 2016
Active Locations (1)
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1
University of Utah Health Sciences Center
Salt Lake City, Utah, United States, 84132