Status:
COMPLETED
Collection of Blood Samples for DNA in Motor Neuron Disease
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Motor Neuron Diseases
Eligibility:
All Genders
18+ years
Brief Summary
This study will collect blood samples from patients with primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) to be used for research on genetic causes of motor neuron diseases and ...
Detailed Description
OBJECTIVE: The causes of sporadic motor neuron diseases, primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) are unknown. Genes have been identified for some forms of familial mot...
Eligibility Criteria
Inclusion
- PRIMARY LATERAL SCLEROSIS INCLUSION CRITERIA:
- Patients with PLS, aged 18 and older, must meet the diagnostic criteria proposed by Pringle (1992), incorporating Santa Clara (2004) consensus for pure PLS.
- Clinical:
- Insidious onset in adulthood, progressive course
- No family history
- Disease duration greater than 3 years without lower motor neuron clinical signs
- Clinical signs restricted to corticospinal/corticobulbar tract dysfunction
- Imaging:
- Brain MRI normal (except cortical atrophy)
- Normal cervical spine
- Negative chest X-ray, negative mammograms in women
- EMG after 3 years, but within last 3 years, showing no active denervation.
- Normal serological studies for serum chemistry, Vitamin B12, Vitamin E levels, very long-chain fatty acids.
- Negative serology for syphilis, Lyme disease, HTLV 1 and 2.
- AMYOTROPHIC LATERAL SCLEROSIS INCLUSION CRITERIA:
- Patients with ALS, aged 18 and older, must fulfill the revised El Escorial criteria for probable or definite ALS.
- Probable ALS: Upper and Lower motor neuron signs are present in more than two regions, but some UMN signs must be rostral to LMN signs.
- Definite ALS: Upper and Lower motor neuron signs are present in more than three regions.
- EXCLUSION CRITERIA:
- None
Exclusion
Key Trial Info
Start Date :
August 7 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 9 2013
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00362362
Start Date
August 7 2006
End Date
September 9 2013
Last Update
October 6 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892