Status:
COMPLETED
The Association of Platelet Function and Endothelial Function of the Brachial Artery
Lead Sponsor:
Sheba Medical Center
Conditions:
Coronary Artery Disease
Endothelial Function
Eligibility:
All Genders
18+ years
Brief Summary
The proposed study is a prospective one, and will be held on consecutive individuals undergoing the non-invasive brachial artery flow-mediated dilation (FMD) ultrasound for endothelial function at the...
Detailed Description
Background: Previous studies have shown a significant association between endothelial dysfunction and CAD and cardiovascular risk factors. Since the endothelium is a systemic organ, endothelial dysfun...
Eligibility Criteria
Inclusion
- Healthy subjects (i.e., subjects without any history of chest pain or myocardial infarction, coronary artery bypass grafting surgery, coronary angiography with angioplasty and/or stenting, cerebrovascular accident, or peripheral vascular disease) with normal electrocardiograms and echocardiography on admission, and patients with coronary artery disease(i.e, patients with history of myocardial infarction, coronary artery bypass grafting operation, coronary angiography with angioplasty or stenting, heart failure secondary to coronary artery disease, or cerebrovascular accident).
Exclusion
- Exclusion criteria included atrial fibrillation, sinus bradycardia (heart rate \< 50 bpm) without pacemaker, sick sinus syndrome, second or third degree AV block, intolerance to nitrates, renal failure with serum creatinine \> 3 mg/dl, history of drug or alcohol abuse, chronic liver disease, or refusal to sign the informed consent form.
Key Trial Info
Start Date :
January 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2008
Estimated Enrollment :
151 Patients enrolled
Trial Details
Trial ID
NCT00363818
Start Date
January 1 2006
End Date
March 1 2008
Last Update
April 11 2008
Active Locations (2)
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1
Heart Center, Sheba Medical Center
Tel Litwinsky, Israel, 52621
2
The Heart Institute, Sheba Medical Center
Tel Litwinsky, Israel, 52621