Status:
COMPLETED
Low Sodium Diet and Behavioral Intervention for Reversing Arterial Stiffening in Overweight Individuals
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cardiovascular Diseases
Obesity
Eligibility:
All Genders
20-45 years
Phase:
NA
Brief Summary
Obese individuals are at risk for developing cardiovascular disease (CVD). Increasing physical activity, losing weight, and reducing sodium intake may reverse arterial stiffness and blood vessel damag...
Detailed Description
CVD includes diseases that affect the heart and blood vessels. Arterial stiffness, in which arteries harden and become less flexible, increases the risk of developing CVD. Arterial stiffness increases...
Eligibility Criteria
Inclusion
- Body mass index (BMI) between 25 and 35
Exclusion
- High blood pressure currently being treated with medication
- Blood pressure greater than or equal to 140/90 mm Hg on two consecutive study visits
- Diabetes, defined as either a fasting glucose test result of .126 or current use of hypoglycemic medications
- Currently taking hyperlipidemia medication
- Currently taking vasoactive medications
- History of known atherosclerotic disease (e.g., angina, heart attack, lower extremity arterial disease)
- Underlying inflammatory condition (e.g., systemic lupus erythematosus, rheumatoid arthritis)
- Chronic infection
- Current participation in a formal exercise or weight loss program
- Pregnant or planning to become pregnant during the study
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
349 Patients enrolled
Trial Details
Trial ID
NCT00366990
Start Date
January 1 2007
End Date
June 1 2013
Last Update
March 8 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15260