Status:
COMPLETED
Problem Adaptation Therapy (PATH) vs. Supportive Therapy in Treating Depressed, Cognitively Impaired Older Adults
Lead Sponsor:
Weill Medical College of Cornell University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
This study will evaluate the efficacy of Problem Adaptation Therapy (PATH) vs. Supportive Therapy for Cognitively Impaired (ST-CI) older adults in reducing depression and disability in treating depres...
Detailed Description
Depression, cognitive impairment, and disability often coexist in older adults and can lead to patient suffering and family disruption. Moreover, many depressed, cognitively impaired older adults have...
Eligibility Criteria
Inclusion
- Meets Diagnostic and Statistical Manual for Mental Disorders(DSM)IV criteria for unipolar major depression
- Severity of depression greater than or equal to 17 on MADRS
- Disability as determined by at least 1 impairment in instrumental activities of daily living
- Evidence of executive dysfunction or impairment in at least one of the following cognitive domains of Dementia Rating Scale (DRS): attention, construction, conceptualization, and memory (\[scaled score less than 7\] adjusted for age and race based on Mayo's older participants normative data)
- Family member or caregiver able and willing to participate in treatment
- Not currently taking antidepressants, cholinesterase inhibitors, or memantine or on a stable dosage for 8 weeks prior to study entry with no medical recommendation for change of these agents in the near future
Exclusion
- High suicide risk
- Axis I psychiatric disorder or substance abuse other than unipolar major depression or nonpsychotic depression
- Axis II diagnosis of antisocial personality
- Moderate to severe dementia: DRS total score corresponding to moderate or more severe impairment (scaled score less than or equal to 5)
- Acute or severe medical illness (e.g., delirium; metastatic cancer; decompensated cardiac; liver or kidney failure; major surgery; stroke; myocardial infarction during the 3 months prior to entry)
- Currently taking drugs known to cause depression (e.g., reserpine, alpha-methyl-dopa, steroids)
- Currently receiving psychotherapy
- Aphasia
- Sensory problems
- Inability to speak English
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT00368940
Start Date
April 1 2006
End Date
September 1 2011
Last Update
July 24 2017
Active Locations (1)
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1
Cornell Institute of Geriatric Psychiatry
White Plains, New York, United States, 10605