Status:
WITHDRAWN
Bumetanide Versus Furosemide in Heart Failure
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborating Sponsors:
University of Western Ontario, Canada
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Patients with NYHA FC II-III heart failure will be randomized in a cross-over fashion to 8 weeks of bumetanide versus furosemide therapy (equipotent dose), to test whether bumetanide therapy has a sup...
Detailed Description
Insulin resistance is common in patients with heart failure (HF) and is associated with a worse functional capacity and more severe symptoms of heart failure. The majority of HF patients take furosemi...
Eligibility Criteria
Inclusion
- Men and women ≥18 years of age
- NHYA FC II or III HF AND documented LVEF ≤40% within 6 months prior to study entry
- Taking 20 mg to 80 mg furosemide orally once or twice per day
- No changes to cardiac medications for 3 months prior to study entry and no anticipated changes of medications for the duration of the study
- No changes to oral anti-diabetic medications (if applicable) for 3 months prior to study entry, and no anticipated changes for the duration of the study (metformin, sulphonylurea type, glitazone type)
- Ability to provide written consent
Exclusion
- Known sensitivity to bumetanide
- Myocardial infarction, coronary angioplasty, coronary artery bypass surgery, admission for HF or unstable angina within a 3 month period prior to study recruitment
- Planned coronary intervention within 6 months
- Patients who are taking insulin
- Patients with chronic renal (serum creatinine ≥ 200 μmol/L) or hepatic impairment (known cirrhosis or AST or ALT \> 1.5 x upper limit of normal)
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00372762
Start Date
January 1 2011
End Date
June 1 2013
Last Update
March 27 2014
Active Locations (1)
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1
University Hospital, London Health Sciences Centre
London, Ontario, Canada, N6A 5A5