Status:
COMPLETED
Procoagulant Effects of Hyperglycemia After Acute Stroke: A Pilot Study
Lead Sponsor:
Temple University
Conditions:
Ischemic Stroke
Hyperglycemia
Eligibility:
All Genders
18+ years
Brief Summary
Between twenty and fifty percent of people who have acute stroke have hyperglycemia (high blood sugar) with it. The purpose of this study is to examine the relationships between diabetes mellitus, hyp...
Detailed Description
The purpose of this study is to examine the relationships between diabetes mellitus, hyperglycemia,whole blood tissue factor procoagulant activity (TF-PCA) and plasma factorVIIa (FVIIa) in ten patient...
Eligibility Criteria
Inclusion
- Patients aged \> 18 years presenting to the Emergency Department with symptoms of acute ischemic stroke will be included for study.
- Acute stroke patients with normal blood glucose levels and patients with fingerstick blood glucose level of greater than or equal to 150 mg/dl will be eligible for study.
- Acute Stroke will be defined as an acute disturbance of cerebral function of presumed vascular origin causing a neurological deficit of less than 24 hours duration.
- Patients must have an NIH Stroke Scale Score of 4 to 23. Patients awakening with symptoms of stroke will be considered to have had their stroke at the time when last awake without symptoms.
Exclusion
- Patients presenting after 24 hours of symptom onset. When the actual time of onset is unknown, the time when last observed to be symptom-free will be used.
- Patients with NIH scale of less than 4 or greater than 23.
- Complete or substantial resolution of symptoms before randomization.
- Patients with a previously disabling stroke (modified Rankin score \> 3)
- Patients with other systemic disease such as infection (eg pneumonia, etc)
- Patients with hemorrhage visualized on CT.
- Patients who are unwilling or unable to give informed consent, or for whom a legally authorized representative is not able to consent.
- Pregnant patients.
Key Trial Info
Start Date :
October 1 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2005
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT00373269
Start Date
October 1 2001
End Date
November 1 2005
Last Update
February 27 2017
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