Status:
COMPLETED
High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding
Lead Sponsor:
Casa Sollievo della Sofferenza IRCCS
Conditions:
Peptic Ulcers
Upper Gastrointestinal Bleeding
Eligibility:
All Genders
18-90 years
Phase:
PHASE3
Brief Summary
High intravenous dosage of Proton Pump Inhibitors is not better than standard dosage in bleeding peptic ulcers successfully treated by endoscopic therapy
Detailed Description
The recent Canadian consensus conference on the management of patients with non-variceal upper gastrointestinal bleeding recommends a high regimen of PPIs, consisting in a dosage of 80-mg bolus follow...
Eligibility Criteria
Inclusion
- Consecutive patients admitted for upper gastrointestinal bleeding secondary to peptic ulcers that have been successfully treated with endoscopic therapy
Exclusion
- Variceal esophageal bleeding
- Concurrent PPI use
- Moribund patients
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
End Date :
March 1 2007
Estimated Enrollment :
450 Patients enrolled
Trial Details
Trial ID
NCT00374101
Start Date
January 1 2005
End Date
March 1 2007
Last Update
April 5 2007
Active Locations (10)
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1
Division of Internal Medicine
Polla, Salerno, Italy
2
Division of Gastroenterology
Caserta, Italy
3
DIvision of Gastroenterology
Como, Italy
4
Division of Gastroenterology
Cosenza, Italy