Status:
COMPLETED
Tranexamic Acid, Hemorrhage and Transfusions After Combined Aortic Valve Replacement and Coronary Artery Bypass Surgery.
Lead Sponsor:
St. Olavs Hospital
Conditions:
Hemorrhage
Eligibility:
All Genders
70+ years
Phase:
NA
Brief Summary
In this study we will investigate whether tranexamic acid given as an intravenous bolus injection before start of surgery, followed by a continuous infusion during surgery reduces, perioperative hemos...
Detailed Description
It has previously been shown that elderly patients show signs of increased perioperative hemostatic activation after coronary artery bypass grafting. In particular, compared to younger patients, elder...
Eligibility Criteria
Inclusion
- Patients above 70 years of age scheduled for combined aortic valve replacement and coronary artery bypass surgery.
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Exclusion
- Patients younger than 70 years of age. Patients scheduled for other procedures than combined aortic valve replacement and coronary artery bypass surgery. Patients who are not treated with aspirin. Patients with a medical condition known to influence the hemostatic system. Patients treated with drugs other than aspirin during the last week before surgery that may influence the hemostatic system, such as warfarin (coumarin), non-steroidal antiinflammatory drugs, clopidogrel, heparin, low molecular heparins. Patients who are treated with systemic steroids. Patients with a serum creatinin concentration above 140 micromol/l. Patients with an INR above 1.5. Patients who are not able to give written informed concent.
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Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT00375466
Start Date
September 1 2006
End Date
December 1 2008
Last Update
December 13 2012
Active Locations (1)
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1
St. Olav University Hospital
Trondheim, Norway, 7006