Status:
COMPLETED
HRT Versus Etidronate for Osteoporosis and Fractures in Asthmatics Receiving Glucocorticoids.
Lead Sponsor:
British Thoracic Society
Conditions:
Osteoporosis
Eligibility:
FEMALE
Up to 59 years
Phase:
PHASE4
Brief Summary
To determine and compare the effects of Hormone replacement therapy (HRT), etidronate, HRT plus etidronate and no treatment over 5 years in the prevention and treatment of glucocorticoid-induced osteo...
Detailed Description
Multicentre trial involving 13 hospitals in United Kingdom, with patients entered by 17 Consultant Chest Physicians. Consenting patients were randomised in a central office to either HRT, etidronate, ...
Eligibility Criteria
Inclusion
- Postmenopausal, asthmatic outpatients under 60 years of age on long-term oral or inhaled glucocorticoid treatment for at least one year.
Exclusion
- Hysterectomy, history of breast or endometrial cancer, undiagnosed pelvic or breast mass, untreated hypertension.
Key Trial Info
Start Date :
August 1 1992
Trial Type :
INTERVENTIONAL
End Date :
October 1 2000
Estimated Enrollment :
750 Patients enrolled
Trial Details
Trial ID
NCT00376662
Start Date
August 1 1992
End Date
October 1 2000
Last Update
September 15 2006
Active Locations (2)
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1
Department of Chest Medicine, Llandough Hospital
Cardiff, Wales, United Kingdom, CF62 2XX
2
Department of Chest Medicine, Llandough Hospital,
Cardiff, Wales, United Kingdom, CF64 2XX