Status:
COMPLETED
Muscle Contraction in Patients With Focal Hand Dystonia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Focal Hand Dystonia
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine and compare brain activity in people with focal hand dystonia (FHD) and healthy volunteers to obtain further knowledge about the underlying cause of FHD. Patients with dystonia...
Detailed Description
OBJECTIVE: In sensory systems, a neural mechanism called surround inhibition (SI) sharpens sensation by creating an inhibitory zone around the central core of activation. This principle was described...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- PATIENTS:
- 18 years old or older
- Presence of FHD, for Experiment 5, 6, 7 and 8 the affected limb has to be the right and dominant side
- HEALTHY VOLUNTEERS:
- 18 years old or older
- Right handedness
- Absence of dystonia or other neurological disorder with any effect on the motor or sensory systems
- EXCLUSION CRITERIA:
- PATIENTS AND HEALTHY VOLUNTEERS:
- Concurrent significant medical, surgical, neurological or psychiatric condition
- Taking the following medications: antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines
- Patients- Received botulinum toxin injection within 3 months of starting the protocol
- For TMS: Presence of pacemaker, implanted medical pump, metal plate or metal object in skull or eye
- History of seizure disorder
- Known history of hearing loss
- For MRI: Presence of pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, or shrapnel fragments. Welders and metal workers are also at risk for injury because of possible small metal fragments in the eye of which they may be unaware.
- Pregnancy.
Exclusion
Key Trial Info
Start Date :
September 11 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 11 2011
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT00376753
Start Date
September 11 2006
End Date
May 11 2011
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892