Status:
UNKNOWN
Study of the Effects of Muscular Activity on Iron Metabolism
Lead Sponsor:
Rennes University Hospital
Conditions:
Iron Overload
Iron Deficiency
Eligibility:
MALE
18-40 years
Phase:
NA
Brief Summary
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and uri...
Detailed Description
Hemojuvelin has been described as interfering with hepcidin, a key regulator of iron homeostasis. Hemojuvelin is mainly produced by muscle, and the relationship between exercise and iron metabolism ca...
Eligibility Criteria
Inclusion
- Male individuals aged between 18 and 40 years old
- Body mass index (BMI) between 18 and 25
- Normal at clinical examination
- Normal biological variables
- Written informed consent
Exclusion
- Mutation C282Y of the HFE gene
- Iron metabolism abnormality
- Inflammatory syndrome
- Chronic pathology or ongoing treatment
- Tobacco smoking, alcohol consuming more than 30g/day
- History of transfusion or blood-giving within 3 months
- Positive serology for hepatitis B virus (HBV), hepatitis C virus (HCV) or HIV.
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00378469
Start Date
September 1 2006
Last Update
July 12 2007
Active Locations (2)
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1
Service des Maladies du Foie - Hôpital de Pontchaillou
Rennes, France, 35033
2
Unité de Biologie et Médecine du Sport - Hôpital de Pontchaillou
Rennes, France, 35033