Status:
ACTIVE_NOT_RECRUITING
Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Previously Untreated Stage I or Stage II Hodgkin's Lymphoma
Lead Sponsor:
European Organisation for Research and Treatment of Cancer - EORTC
Conditions:
Lymphoma
Eligibility:
All Genders
15-70 years
Phase:
PHASE3
Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill cancer cells. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopp...
Detailed Description
OBJECTIVES: * Evaluate the efficacy of mantle field radiotherapy, in terms of overall survival, in patients with previously untreated stage I or II Hodgkin's lymphoma (HL) with a very favorable progn...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed supradiaphragmatic Hodgkin's lymphoma
- Stage I or II disease
- Previously untreated disease
- PATIENT CHARACTERISTICS:
- WHO performance status 0-2
- Normal life expectancy
- No severe cardiac, pulmonary, neurologic, or metabolic disease that would interfere with normal life expectancy or study treatment
- No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix
- No psychological, familial, socioeconomic, or geographic circumstance that would preclude proper staging or study compliance
- HIV negative
- Not pregnant
- Fertile patients must use effective contraception
- PRIOR CONCURRENT THERAPY:
- No prior staging laparotomy
- No prior biologic therapy, chemotherapy, endocrine therapy, radiotherapy, or surgery for this malignancy
Exclusion
Key Trial Info
Start Date :
September 1 1993
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
1158 Patients enrolled
Trial Details
Trial ID
NCT00379041
Start Date
September 1 1993
Last Update
August 5 2025
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