Status:
UNKNOWN
Impact of Different Dialysis on Sleep Apnea in Patients With Renal Failure
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Collaborating Sponsors:
Gambro Renal Products, Inc.
McGill University
Conditions:
Sleep Apnea
End Stage Renal Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether hemodiafiltration, a new form of hemodialysis can improve sleep apnea in patients with end stage kidney disease.
Detailed Description
Sleep apnea or breathing problems during sleep are frequent, occurring in 6% of the general population. However, more than half of all patients on dialysis suffer from breathing problems related to sl...
Eligibility Criteria
Inclusion
- Patients currently stable on a thrice weekly hemodialysis regimen for a minimum of 3 months
- Patients with vascular access and no contraindications to anticoagulation
- Presence of sleep-related breathing disorder defined as a mean apnea-hypopnea per hour of recording greater than 10 based on cardiorespiratory monitoring
Exclusion
- Patients already on hemodiafiltration therapy
- Patients already on treatment for sleep disordered breathing.
- Patients with significant neuromuscular disease
- Patients with an expected lifespan \< 1 year
- Patients unable to complete sleep related quality of life questionnaires and consent forms due to language barriers or dementia
- Patients with known substance abuse
- Patients with a respiratory disturbance index greater than 30 with active cardiovascular disease defined by unstable angina, myocardial infarction within 3 months or an Epworth sleepiness score greater than 15 while actively working in a stress situation (for example bus driver, taxi driver). These patients will be evaluated by a sleep specialist.
- Living further than 30 km from dialysis centre
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
End Date :
December 1 2007
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00380848
Start Date
March 1 2006
End Date
December 1 2007
Last Update
April 12 2007
Active Locations (1)
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1
Royal Victoria Hospital - Dialysis Unit
Montreal, Quebec, Canada