Use of Clarithromycin in Mustard-Induced Bronchiolitis

Status:

COMPLETED

Use of Clarithromycin in Mustard-Induced Bronchiolitis

Lead Sponsor:

Baqiyatallah Medical Sciences University

Conditions:

Bronchiolitis Obliterans

Acute Obliterating Bronchiolitis

Eligibility:

MALE

Phase:

PHASE3

Brief Summary

We looked for the effectiveness of low-dose long-term prescription of clarithromycin in mustard-induced chronic pulmonary lesions, especially bronchiolitis obliterans

Eligibility Criteria

Inclusion

His/her own will to participate
Documented chemical exposure
Clinical, spirometric and radiological findings were compatible with BO on High Resolution Computed Tomography (HRCT)

Exclusion

any drug reactions during the trial
history of sensitivity to macrolides
diarrhea, gray stool, jaundice, eosinophilia, acute cholestatic hepatitis, pruritis, dark urine, abdominal pain, osteomatosis, depression, taste change, behavioural changes, early fatigue, odynophagia, glossitis , dizziness
co-adminstration of: terfenadine, theophylline, carbamazepine, ergotamine, dihydroergotamine, warfarin, cisapride, digoxin, triazolam, phenytoin, steroids, any immunosuppressive, any systemic antibiotics
using drugs that he/she cannot discontinue
using drugs with potential interaction
subject will to exit from the trial
history of lobe resection of lung
history of exacerbation in the last month prior to the beginning of trial
continuous need to oxygen
use of corticosteroids in last week prior to the trial beginning
Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an infection that necessitated the use of an antibiotic
exacerbating of subjects
creatinine srum level more than normal
increasing ALT, AST levels
total bilirubin more twice than normal
subjects who did not use their drugs properly

Key Trial Info

Start Date :

Trial Type :

INTERVENTIONAL

End Date :

Estimated Enrollment :

Patients enrolled

Trial Details

Trial ID

NCT00381147

Last Update

January 7 2009

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