Status:
COMPLETED
Study to Assess GW642444 in Asthma Patients
Lead Sponsor:
GlaxoSmithKline
Conditions:
Pulmonary Disease, Chronic Obstructive
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
This is a study of GW642444M, a long-acting beta 2 specific agonist. This study will examine GW642444M via the inhaled route and will assess the efficacy, safety, tolerability, pharmacodynamics and ph...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Subjects with a documented history of persistent asthma, with the exclusion of other significant pulmonary diseases
- Female subjects of non-child bearing potential (i.e. post-menopausal or surgically sterile)
- Subjects who are current non-smokers, who have not used any inhaled tobacco products (snuff is permitted) in the 12 month period preceding the screening visit and who have a pack history of less than 10 pack years.
- Subjects with clinically stable persistent asthma within the 4 weeks preceding the screening visit and with a screening pre-bronchodilator FEV1 between 60 and 90% predicted (having abstained from bronchodilators for the required period). Predicted values are based on the ECCS 1993 normal ranges
- During the screening visit, subjects must demonstrate the presence of reversible airway disease, defined as an increase in FEV1 of greater than 12.0% over baseline and an absolute change of greater than 300 mL within 30 minutes following a single 400 mcg salbutamol dose.
- Subjects who are currently taking ICS at a total daily dose of 200 to 500 mcg of FP or equivalent ICS
- Exclusion criteria:
- Subjects who have a past or present disease, which as judged by the Investigator and the Medical Monitor, which may affect the safety of the subject or outcome of this study
- A screening Holter ECG tracing that reveals clinically concerning arrhythmias (including, but not limited to, ventricular ectopic runs of 4 beats, R on T phenomena, bigeminy, trigeminy).
- A mean QTc(B) value at screening \>430 msec (male) / \>450 msec (female) or an ECG that is not suitable for QT measurements (e.g. poorly defined termination of the T wave).
- Any adverse reaction including immediate or delayed hypersensitivity to any ß2 agonist or sympathomimetic drug, or known or suspected sensitivity to the constituents of GW642444 inhalation powder (e.g., lactose or COA).
- Subjects weighing \< 50 kg
- Subjects who have participated in any GSK study involving administration of COA.
Exclusion
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2007
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00381667
Start Date
August 1 2006
End Date
January 1 2007
Last Update
October 28 2016
Active Locations (2)
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1
GSK Investigational Site
Clayton, Victoria, Australia, 3168
2
GSK Investigational Site
Wellington, New Zealand, 6001