Status:
COMPLETED
Clinical Pharmacogenomics of Antidepressant Response
Lead Sponsor:
National Health Research Institutes, Taiwan
Collaborating Sponsors:
National Science and Technology Council, Taiwan
Chang Gung Memorial Hospital
Conditions:
Depression
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to understand how genetic polymorphisms influence the efficacy and side effect profiles of Paroxetine and Escitalopram for major depression treatment.
Detailed Description
Despite remarkable progress in recent decades in modern psychopharmacotherapy, patients vary substantially in their response to antidepressants, ranging from total remission to complete treatment fail...
Eligibility Criteria
Inclusion
- self-identified as of Taiwanese/Chinese ethnic background, and report that both of their parents and all four or three of their grandparents are members of the same ethnic group;
- HAMD-21 \> 17 plus MDE (i.e., current major depressive episode) based on SCID;
- male or female, who, if of child-bearing potential, agrees to use effective contraception including the regular use of contraceptive pills, intra-uterine devises or abstinence;
- age \>= 18;
- capable of giving informed consent;
Exclusion
- diagnosis of schizophrenia, schizophreniform disorder, schizoaffective disorder, schizotypal disorder, psychotic depression, bipolar disorders;
- current drug or alcohol abuse or dependence or history of drug or alcohol abuse or dependence within the past 6 months;
- unstable medical or neurological conditions that are likely to interfere with the treatment of depression;
- history of allergy to antidepressants;
- history of seizure disorder;
- pregnancy;
- active suicidal ideation or other safety issues determined by the clinician to not be suitable for inclusion in the study;
Key Trial Info
Start Date :
January 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
402 Patients enrolled
Trial Details
Trial ID
NCT00384020
Start Date
January 1 2006
End Date
January 1 2010
Last Update
February 1 2010
Active Locations (4)
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1
Song-De Branch, Taipei City Hospital
Taipei, Taipei, Taiwan, 11000
2
Municipal Wan Fang Hospital
Taipei, Taipei, Taiwan, 11600
3
Mackay Memorial Hospital
Taipei, Taipei, Taiwan, 25115
4
Chang Gung Memorial Hospital
Taoyuan District, Taoyuan, Taiwan, 33305