Status:
COMPLETED
Effect of Chronic Changes in Heart Rate on Congestive Heart Failure
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
American Heart Association
Conditions:
Heart Failure, Congestive
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This will be a double blind randomized crossover study of patients with congestive heart failure and a heart rate dependent upon a permanent pacemaker. Thus, at all times the heart rate can be maintai...
Detailed Description
This study is a double-blind, randomized, cross-over study of patients with congestive heart failure and a heart rate dependent on a permanent pacemaker. Thus, at all times the heart rate can be maint...
Eligibility Criteria
Inclusion
- Patients must have symptomatic congestive heart failure, NYHA Class II to IV symptoms and an ejection fraction \< 40% by nuclear ventriculography within the previous 6 months. Patients must be stable with no change in dosage on conventional therapy (including digoxin, diuretics, ACE inhibitors, hydralazine, nitrates, angiotensin II receptor blockers and/or beta blocker) for at least 4 weeks
Exclusion
- active alcohol or illicit drug use
- myocardial infarction or unstable angina within the previous 3 months
- obstructive valvular disease
- exercise induced sustained arrhythmias or symptomatic myocardial ischemia
- pregnancy
- psychiatric disorder
- non-compliance with medical regimen
Key Trial Info
Start Date :
November 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2005
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00389649
Start Date
November 1 2001
End Date
June 1 2005
Last Update
December 20 2021
Active Locations (1)
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1
University of Maryland
Baltimore, Maryland, United States, 21201