Status:
COMPLETED
Effect of Metformin on Lactate Metabolism
Lead Sponsor:
Centre de Recherche en Nutrition Humaine Rhone-Alpe
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Hyperlactatemia
Eligibility:
MALE
18-30 years
Phase:
PHASE1
PHASE2
Brief Summary
The main objective of this study is to evaluate the influence of metformin on lactate metabolism. The main outcome is the lactate production following an exogenous lactate overload in healthy male su...
Detailed Description
Study design: Physiological study, controlled, open, non randomised Healthy male subjects, 18 to 30 years old Principal objective : To evaluate the influence of metformin on lactate metabolism (prod...
Eligibility Criteria
Inclusion
- Healthy male subjects, 18 to 30 years
- Body mass index (BMI) between 21 and 25 kg/m2 inclusive
- Informed consent
Exclusion
- Ward of court or under guardianship (sheltered adults)
- Adult unable to express their consent
- Person deprived of freedom by judicial or administrative decision
- Person hospitalised without their consent
- Person under legal protection
- Existence of a previously diagnosed pathology
- Existence of a metabolic condition (obesity, diabetes) or a family history of such
- Ongoing medical treatment
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00390273
Start Date
December 1 2006
End Date
October 1 2007
Last Update
October 7 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Centre Hospitalier Universitaire de Grenoble
Grenoble, France, 38043